- Title
- Testosterone to estradiol ratio and plaque inflammation: mechanistic insights and biomarker potential?
- Creator
- Figtree, Gemma A.; Ngo, Doan T. M.; Bubb, Kristen J.
- Relation
- Cardiovascular Research Vol. 115, Issue 2, p. 255-257
- Publisher Link
- http://dx.doi.org/10.1093/cvr/cvy260
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2019
- Description
- Despite the now clear role of inflammation in atherosclerotic plaque development, progression and instability, our understanding of endogenous factors regulating this is limited. Our strategies for measuring inflammation relevant to the arterial wall remains relatively primitive, e.g. the highly sensitive, but non-specific C-reactive protein (CRP). Improved understanding of the specific factors upstream of inflammation has the potential to identify markers with higher specificity for atherosclerosis risk. New insights may also aid the development of novel therapeutic targets, which may act in a synergistic manner with current standard pharmacotherapy targeting lipids and neurohormonal abnormalities.
- Subject
- testosterone; estradiol ratio; plaque inflammation; mechanistic insights
- Identifier
- http://hdl.handle.net/1959.13/1451092
- Identifier
- uon:44090
- Identifier
- ISSN:0008-6363
- Language
- eng
- Reviewed
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